Haematologica, Vol 95, Issue 3, 432-439 doi:10.3324/haematol.2009.010991
Copyright © 2010 by Ferrata Storti Foundation
Teresa Marafioti1 ,
Jennifer C. Paterson1 ,
Erica Ballabio1 ,
Andreas Chott2 ,
Yasodha Natkunam3 ,
Manuel Rodriguez-Justo4 ,
Anne Plonquet5 ,
Socorro M. Rodriguez-Pinilla6 ,
Wolfram Klapper7 ,
Martin-L. Hansmann8 ,
Stefano A. Pileri9 ,
Peter G. Isaacson4 ,
Harald Stein10 ,
Miguel A. Piris6 ,
David Y. Mason1 ,
Philippe Gaulard11
Copyright © 2010 by Ferrata Storti Foundation
Malignant Lymphomas |
The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation
1 Leukaemia Research Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK;
2 Department of Pathology, General Hospital Vienna, Vienna, Austria;
3 Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA;
4 Department of Histopathology, University College London Medical School, London, UK;
5 Immunologie Biologique, INSERM U955, Hôpital Henri-Mondor, Créteil, France;
6 Molecular Pathology Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain;
7 Department of Hematopathology and Lymph Node Registry Kiel, Schleswig-Holstein University Hospitals, Kiel, Germany;
8 Department of Pathology, Goethe University School of Medicine, University Clinic Frankfurt am Main, Frankfurt am Main, Germany;
9 Department of Haematology and Clinical Oncology "L and A Seràgnoli", Bologna University School of Medicine, Bologna, Italy;
10 Institute of Pathology, Campus Benjamin Franklin, Charité University Medicine, Berlin, Germany;
11 Department of Pathology, INSERM U955, Hôpital Henri Mondor, Créteil, France
Correspondence: Teresa Marafioti, Leukaemia Research Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, OX3 9DU. E-mail: teresa{at}marafioti.org.uk
Background: T follicular helper (TFH) cells reside in the light zone of germinal centers and are considered the cell of origin of angioimmunoblastic T-cell lymphoma. Recently, CXCL13, PD-1 and SAP were described as useful markers for TFH cells and angioimmunoblastic T-cell lymphoma but also reported in some peripheral T-cell lymphomas, not otherwise specified.
Design and Methods: In the present study the expression pattern of ICOS protein was investigated by immunohistochemistry-based techniques in routine sections of normal lymphoid tissues and 633 human lymphomas.
Results: Cells strongly positive for ICOS were restricted to the light zone of germinal centers and co-expressed TFH-associated molecules. In addition, weak to moderate ICOS expression was observed in a small proportion of FOXP3-positive cells. In lymphomas, ICOS expression was confined to angioimmunoblastic T-cell lymphoma (85/86), peripheral T-cell lymphomas of follicular variant (18/18) and a proportion of peripheral T-cell lymphomas, not otherwise specified (24/56) that also expressed other TFH-associated molecules.
Conclusions: ICOS is a useful molecule for identifying TFH cells and its restricted expression to angioimmunoblastic T-cell lymphoma and a proportion of peripheral T-cell lymphomas, not otherwise specified (showing a TFH-like profile) suggests its inclusion in the antibody panel for diagnosing TFH-derived lymphomas. Our findings provide further evidence that the histological spectrum of TFH-derived lymphomas is broader than previously assumed.
Key words: ICOS, TFH cells, angioimmunoblastic T-cell lymphoma.
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