Editorials and Perspectives:

Marc H.G.P. Raaijmakers

Regulating traffic in the hematopoietic stem cell niche
Haematologica 2010 95: 1439-1441. [Full Text] [PDF] [Disclosures]  

Thorsten Zenz, Daniel Mertens, Stephan Stilgenbauer

Biological diversity and risk-adapted treatment of chronic lymphocytic leukemia
Haematologica 2010 95: 1441-1443. [Full Text] [PDF] [Disclosures]  

Flora Peyvandi, Roberta Palla, Luca A. Lotta

Pathogenesis and treatment of acquired idiopathic thrombotic thrombocytopenic purpura
Haematologica 2010 95: 1444-1447. [Full Text] [PDF] [Disclosures]  

Giuseppe Roberto Burgio, Marco Zecca, Patrizia Comoli, Rita Maccario

Biological individuality and the new frontiers of immunological tolerance in hematopoietic stem cell transplantation
Haematologica 2010 95: 1447-1451. [Full Text] [PDF] [Disclosures]  

Original Article:

Hematopoietic Stem Cells:

Nicole D. Staudt, Wilhelm K. Aicher, Hubert Kalbacher, Stefan Stevanovic, Adriana K. Carmona, Matthew Bogyo, Gerd Klein

Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts
Haematologica 2010 95: 1452-1460. Published online May 21, 2010; doi:10.3324/haematol.2009.018671 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][Supplementary Appendix]  

Richard Ratei, Michael Hummel, Ioannis Anagnostopoulos, Doris Jähne, Renate Arnold, Bernd Dörken, Stephan Mathas, Thomas Benter, Oliver Dudeck, Wolf-Dieter Ludwig, Harald Stein

Common clonal origin of an acute B-lymphoblastic leukemia and a Langerhans’ cell sarcoma: evidence for hematopoietic plasticity
Haematologica 2010 95: 1461-1466. Published online April 26, 2010; doi:10.3324/haematol.2009.021212 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Sickle Cell Disease:

Ashaunta Tumblin, Anitaben Tailor, Gerard T. Hoehn, A. Kyle Mack, Laurel Mendelsohn, Lita Freeman, Xiuli Xu, Alan T. Remaley, Peter J. Munson, Anthony F. Suffredini, Gregory J. Kato

Apolipoprotein A-I and serum amyloid A plasma levels are biomarkers of acute painful episodes in patients with sickle cell disease
Haematologica 2010 95: 1467-1472. Published online April 7, 2010; doi:10.3324/haematol.2009.018044 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Myelodysplastic/Myeloproliferative Neoplasms:

Thomas Ernst, Andrew Chase, Katerina Zoi, Katherine Waghorn, Claire Hidalgo-Curtis, Joannah Score, Amy Jones, Francis Grand, Andreas Reiter, Andreas Hochhaus, Nicholas C.P. Cross

Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms
Haematologica 2010 95: 1473-1480. Published online April 26, 2010; doi:10.3324/haematol.2010.021808 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][S]  

Acute Lymphoblastic Leukemia:

Ryoko Okamoto, Seishi Ogawa, Daniel Nowak, Norihiko Kawamata, Tadayuki Akagi, Motohiro Kato, Masashi Sanada, Tamara Weiss, Claudia Haferlach, Martin Dugas, Christian Ruckert, Torsten Haferlach, H. Phillip Koeffler

Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia
Haematologica 2010 95: 1481-1488. Published online April 30, 2010; doi:10.3324/haematol.2009.011114 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][Supplementary Appendix]  

Boris Labar, Stefan Suciu, Roel Willemze, Petra Muus, Jean-Pierre Marie, Georges Fillet, Zwi Berneman, Branimir Jaksic, Walter Feremans, Dominique Bron, Harm Sinnige, Martin Mistrik, Gerard Vreugdenhil, Robrecht De Bock, Damir Nemet, Caroline Gilotay, Sergio Amadori, Theo de Witte on behalf of the EORTC Leukemia Group

Dexamethasone compared to prednisolone for adults with acute lymphoblastic leukemia or lymphoblastic lymphoma: final results of the ALL-4 randomized, phase III trial of the EORTC Leukemia Group
Haematologica 2010 95: 1489-1495. Published online April 7, 2010; doi:10.3324/haematol.2009.018580 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Hodgkin's Lymphoma:

Noemi Puig, Melania Pintilie, Tara Seshadri, Khalil al-Farsi, Tracy Nagy, Norman Franke, Richard Tsang, Armand Keating, Michael Crump, John Kuruvilla

Different response to salvage chemotherapy but similar post-transplant outcomes in patients with relapsed and refractory Hodgkin’s lymphoma
Haematologica 2010 95: 1496-1502. Published online May 11, 2010; doi:10.3324/haematol.2009.019943 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Malignant Lymphomas:

Saskia A.M. van de Schans, Maryska L.G. Janssen-Heijnen, Marten R. Nijziel, Ewout W. Steyerberg, Dick Johan van Spronsen

Validation, revision and extension of the Mantle Cell Lymphoma International Prognostic Index in a population-based setting
Haematologica 2010 95: 1503-1509. Published online May 21, 2010; doi:10.3324/haematol.2009.021113 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Chronic Lymphocytic Leukemia:

Maria Baou, Susan L. Kohlhaas, Michael Butterworth, Meike Vogler, David Dinsdale, Renata Walewska, Aneela Majid, Eric Eldering, Martin J.S. Dyer, Gerald M. Cohen

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells
Haematologica 2010 95: 1510-1518. Published online April 7, 2010; doi:10.3324/haematol.2010.022368 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][Supplementary Appendix]  

Millaray Marincevic, Nicola Cahill, Rebeqa Gunnarsson, Anders Isaksson, Mahmoud Mansouri, Hanna Göransson, Markus Rasmussen, Mattias Jansson, Fergus Ryan, Karin Karlsson, Hans-Olov Adami, Fred Davi, Jesper Jurlander, Gunnar Juliusson, Kostas Stamatopoulos, Richard Rosenquist

High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with ‘stereotyped’ IGHV3-21 and IGHV4-34 B-cell receptors
Haematologica 2010 95: 1519-1525. Published online April 26, 2010; doi:10.3324/haematol.2009.021014 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][Supplementary Appendix]  

Eva Giné, Antoni Martinez, Neus Villamor, Armando López-Guillermo, Mireia Camos, Daniel Martinez, Jordi Esteve, Xavier Calvo, Ana Muntañola, Pau Abrisqueta, Maria Rozman, Ciril Rozman, Francesc Bosch, Elias Campo, Emili Montserrat

Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia ("accelerated" chronic lymphocytic leukemia) with aggressive clinical behavior
Haematologica 2010 95: 1526-1533. Published online April 26, 2010; doi:10.3324/haematol.2010.022277 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Lymphoproliferative Disorders:

Benoît Bareau, Jérôme Rey, Mohamed Hamidou, Jean Donadieu, Jeff Morcet, Oumedaly Reman, Nicolas Schleinitz, Olivier Tournilhac, Mikael Roussel, Thierry Fest, Thierry Lamy

Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases
Haematologica 2010 95: 1534-1541. Published online April 7, 2010; doi:10.3324/haematol.2009.018481 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Multiple Myeloma:

Hong Chang, Nan Jiang, Hua Jiang, Manujendra N. Saha, Connie Qi, Wei Xu, Donna Reece

CKS1B nuclear expression is inversely correlated with p27^Kip1 expression and is predictive of an adverse survival in patients with multiple myeloma
Haematologica 2010 95: 1542-1547. Published online April 26, 2010; doi:10.3324/haematol.2010.022210 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Heinz Ludwig, Zdenek Adam, Elena Tóthová, Roman Hajek, Boris Labar, Miklós Egyed, Ivan Spicka, Heinz Gisslinger, Johannes Drach, Ingrid Kuhn, Axel Hinke, Niklas Zojer

Thalidomide maintenance treatment increases progression-free but not overall survival in elderly patients with myeloma
Haematologica 2010 95: 1548-1554. Published online April 23, 2010; doi:10.3324/haematol.2009.020586 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Thrombotic Thrombocytopenic Purpura:

X. Long Zheng, Haifeng M. Wu, Dezhi Shang, Erica Falls, Christopher G. Skipwith, Spero R. Cataland, Charles L. Bennett, Hau C. Kwaan

Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura
Haematologica 2010 95: 1555-1562. Published online April 7, 2010; doi:10.3324/haematol.2009.019299 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Thrombosis:

Elisabetta Castoldi, Lisbeth F.A. Maurissen, Daniela Tormene, Luca Spiezia, Sabrina Gavasso, Claudia Radu, Tilman M. Hackeng, Jan Rosing, Paolo Simioni

Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency
Haematologica 2010 95: 1563-1571. Published online April 26, 2010; doi:10.3324/haematol.2010.021923 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][Supplementary Appendix]  

Stem Cell Transplantation:

Andrew McLarnon, Karen P. Piper, Oliver C. Goodyear, Julie M. Arrazi, Premini Mahendra, Mark Cook, Fiona Clark, Guy Pratt, Charles Craddock, Paul. A.H. Moss

CD8⁺ T-cell immunity against cancer-testis antigens develops following allogeneic stem cell transplantation and reveals a potential mechanism for the graft-versus-leukemia effect
Haematologica 2010 95: 1572-1578. Published online May 11, 2010; doi:10.3324/haematol.2009.019539 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][Supplementary Appendix]  

Cell Therapy and Immunotherapy:

Selim Kuçi, Eva Rettinger, Bernhard Voß, Gerrit Weber, Miriam Stais, Hermann Kreyenberg, Andre Willasch, Zyrafete Kuçi, Ewa Koscielniak, Stephan Klöss, Dorothee von Laer, Thomas Klingebiel, Peter Bader

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation
Haematologica 2010 95: 1579-1586. Published online April 7, 2010; doi:10.3324/haematol.2009.019885 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][Supplementary Appendix]  

Decision Making and Problem Solving:

Thrombosis:

Alejandro Lazo-Langner, Jeff Hawel, Walter Ageno, Michael J. Kovacs

Low molecular weight heparin for the treatment of retinal vein occlusion: a systematic review and meta-analysis of randomized trials
Haematologica 2010 95: 1587-1593. Published online March 19, 2010; doi:10.3324/haematol.2010.023614 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Brief Report:

Erythropoiesis:

Emile van den Akker, Timothy J. Satchwell, Stephanie Pellegrin, Geoff Daniels, Ashley M. Toye

The majority of the in vitro erythroid expansion potential resides in CD34^– cells, outweighing the contribution of CD34⁺ cells and significantly increasing the erythroblast yield from peripheral blood samples
Haematologica 2010 95: 1594-1598. Published online April 7, 2010; doi:10.3324/haematol.2009.019828 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][Supplementary Appendix]  

Sickle Cell Disease:

Jeffrey D. Lebensburger, Tamara I. Pestina, Russell E. Ware, Kelli L. Boyd, Derek A. Persons

Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model
Haematologica 2010 95: 1599-1603. Published online April 7, 2010; doi:10.3324/haematol.2010.023325 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][Supplementary Appendix]  

Chronic Myeloid Leukemia:

Eric Lippert, Gabriel Etienne, Marie-Joelle Mozziconacci, Sophy Laibe, Carine Gervais, Stéphane Girault, Nathalie Gachard, Isabelle Tigaud, Nicole Dastugue, François Huguet, Marie-Pierre Fort, Laurence Legros, Virginie Eclache, Francois-Xavier Mahon

Loss of the Y chromosome in Philadelphia-positive cells predicts a poor response of chronic myeloid leukemia patients to imatinib mesylate therapy
Haematologica 2010 95: 1604-1607. Published online April 30, 2010; doi:10.3324/haematol.2009.019109 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Acute Lymphoblastic Leukemia:

Jasmine Healy, Chantal Richer, Mathieu Bourgey, Ekaterini A. Kritikou, Daniel Sinnett

Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia
Haematologica 2010 95: 1608-1611. Published online May 11, 2010; doi:10.3324/haematol.2010.022459 [Abstract] [Full Text] [PDF] [Disclosures and Contributions][Supplementary Appendix]  

Infectious Disorders:

Désirée Caselli, Simone Cesaro, Ottavio Ziino, Giulio Zanazzo, Rosaria Manicone, Susanna Livadiotti, Monica Cellini, Stefano Frenos, Giuseppe M. Milano, Barbara Cappelli, Maria Licciardello, Chiara Beretta, Maurizio Aricò, Elio Castagnola for the "Infection Study Group" of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)

Multidrug resistant Pseudomonas aeruginosa infection in children undergoing chemotherapy and hematopoietic stem cell transplantation
Haematologica 2010 95: 1612-1615. Published online March 19, 2010; doi:10.3324/haematol.2009.020867 [Abstract] [Full Text] [PDF] [Disclosures and Contributions]  

Letter to the Editor:

Myeloid Neoplasms:

Doris Steinemann, Marcel Tauscher, Inka Praulich, Charlotte M. Niemeyer, Christian Flotho, Brigitte Schlegelberger

Mutations in the let-7 binding site - a mechanism of RAS activation in juvenile myelomonocytic leukemia?
Haematologica 2010 95: 1616. Published online May 11, 2010; doi:10.3324/haematol.2010.024984 [Full Text] [PDF] [Disclosures and Contributions]  

Stem Cell Transplantation:

Petra Sovinz, Wolfgang Schwinger, Herwig Lackner, Andrea Nebl, Sabine Sipurzynski, Christian Urban

Short-term cryopreservation of allogeneic stem cells for optimization of transplant conditions in children
Haematologica 2010 95: 1616-1619. Published online April 30, 2010; doi:10.3324/haematol.2009.021592 [Full Text] [PDF] [Disclosures and Contributions]  

Erratum:

ERRATUM
Haematologica 2010 95: 1620. [Full Text] [PDF]  

ERRATUM
Haematologica 2010 95: 1620. [Full Text] [PDF]  

ERRATUM
Haematologica 2010 95: 1620. [Full Text] [PDF]  

ERRATUM
Haematologica 2010 95: 1620. [Full Text] [PDF]  

Online Only Articles:

Norio Asou, Eisaku Iwanaga, Tomoko Nanri, Hiroaki Mitsuya

Successful treatment with low-dose imatinib mesylate of therapy-related myeloid neoplasm harboring TEL-PDGFRB in a patient with acute promyelocytic leukemia
Haematologica 2010 95: e1. [Full Text] [PDF] [Disclosures and Contributions]  

Daniel KL Cheuk

Is stem cell transplantation the treatment of choice in pediatric chronic myeloid leukemia?
Haematologica 2010 95: e3. [Full Text] [PDF] [Disclosures and Contributions]  

Asim F Belgaumi, Ali Al-Shehri

Clinical characteristics and treatment outcome of pediatric patients with chronic myeloid leukemia
Haematologica 2010 95: e4. [Full Text] [PDF] [Disclosures and Contributions]  

Sabine Ponader, Jan A. Burger

Modeling the marrow stem cell niche in vitro: is proximity the key to reproduction?
Haematologica 2010 95: e5. [Full Text] [PDF] [Disclosures and Contributions]  

Pier Mannuccio Mannucci

Bleeding symptoms in heterozygous factor VIII deficiency
Haematologica 2010 95: e6. [Full Text] [PDF] [Disclosures and Contributions]  

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